IT TAKES A LOT OF GUTS-THE HUMAN MICROBIOME IN DISEASE

ALL THEY ASK FOR IN RETURN

microbiome

These friendly bacteria have developed a way to interact within our gut without triggering an immune response against them; to co-exist in our bowels which is incredible when you think about it.[1] All they ask for in return is that we feed, shelter and clothe them. Well perhaps they don’t actually need clothes do they? But we certainly provide food and a nice, warm, humid, blacker than the inside of a cow, stomping ground.

Foods for these wee folks are called “pre-biotics” which consist of numerous indigestible items from the plant kingdom like various dietary fibers. Nutrients are also needed such as polyphenols which act as antibiotics against microbial invasion within the plant kingdom. There is compelling evidence that these same polyphenols can be used to fight off invading pathogens when encountered in our gut.[2] 

This is yet one more reason why you need to eat plenty of fresh fruits and veggies to keep this biotic reactor in tip top shape. To prevent a future colorectal Fukushima which, by the way, is still belching out toxic, radioactive, waste water 24-7 with no end in sight and no ideas on how to fix it. This is the worst nuclear disaster in history. Yet it’s never mentioned or discussed. Now do know why we talk of a truth crisis in the media?

Clinical research has implicated bacterial dysbiosis in a number of diseases of inflammation within the bowel or involving skin or connective tissue. The published associations are reviewed below:

 

THE OBESITY MICROBIOME

Studies have confirmed that obese people have a different makeup of gut flora than thin people.

Fat people,…had more Firmicutes and fewer Bacteroidetes than thin ones.Experiments on mice suggest this is not just a question of the bacteria responding to altered circumstances. They actually assist the process of slimming by suppressing production of a hormone that facilitates the storage of fat, and of an enzyme that stops fat being burned. [3]  

The wrong bacteria can even contribute to malnourishment by not being able to digest carbohydrate or synthesize vitamins.

THE GUT-HEART CONNECTION

The above pales in comparison to the role of gut bacteria and hypertension, a risk factor for heart disease, established through the work of Jeremy Nicholson of Imperial College, London:

And you can geographically map people according to their metabolic patterns, [that is, the metabolites the body produces which end up in the urine].

Britain is the ’51st state’ as we are really in the middle of America. Our lifestyle and our diets and our ethnic mixes are quite similar in many ways to America.

The patterns do not seem to follow genetics, Nicholson said. It has to do with their diet and lifestyle and also gut microorganisms…Some of the compounds they release have drug-like effects. [Emphasis mine]

There is an inverse relationship between formic acid concentration in the urine and blood pressure.People with increased levels of the metabolite formate (formic acid) have lower blood pressure and increased energy intake. Formate arises from the action of microbes in the gut or as a product of metabolism in the body. Note that formate is also a product of NutraSweet® metabolism from methanol.

Professor Paul Elliott a co-author of the research from the Department of Epidemiology and Public Health at Imperial College, added: “The flip-side of this is that whereas a person can’t alter their DNA, they can change their metabolic profile by changing their diet and lifestyle. This means that as we figure out where the problems lie, we should also be able to show people ways to reduce their risk of certain diseases.”[4] [Emphasis mine]

Just one course of antibiotics decreased serum enterolactone levels for 16 months. Serum levels of enterolactone are determined by colonic conversion of plant lignans to enterolactone by intestinal microflora. This study suggests that infrequent antibiotic use has a much longer lasting effect than was previously believed. Recently a study was published showing a clinically significant correlation between high serum enterolactone levels and protection from cardiovascular mortality and breast cancer. In other words there is the possibility that antibiotic use may be a causative factor in heart disease or heart attack and breast cancer.

THE GUT-DIABETES CONNECTION

It has been observed that obese, type II diabetics who receive a Roux-en-Y procedure [a surgical procedure that bypasses much of the small bowel] experience a vanishing of their diabetes in up to 80% of the patients. Experiments conducted on mice by Dr Nicholson and his colleagues show that Roux-en-Y causes the composition of the gut microbiome to change. Dr Nicholson thinks this explains the sudden disappearance of diabetes.[5]

THE GUT AND AUTOIMMUNITY

Dr Nicholson feels that many autoimmune diseases may also be triggered by the gut microbiome. Diseases linked to the microbiome include type-1 diabetes (caused by the autoimmune destruction of insulin-secreting cells), asthma, eczema and multiple sclerosis. In each case some component of the microbiome seems to be confusing the immune system, to the detriment of body cells elsewhere.[6]

In the case of multiple sclerosis, a confirmatory study was published last year by Kerstin Berer and her colleagues at the Max Planck Institute for Immunobiology and Epigenetics in Freiburg, Germany. They showed, again in mice, that gut bacteria are indeed involved in triggering the reaction that causes the body’s immune system to turn against certain nerve cells and strip away their insulation in precisely the way that leads to multiple sclerosis.[7]

THE GUT AND INFLAMMATORY BOWEL DISEASE.

Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive.… [A]nother key question related to this issue is: at what time does the intestinal flora of a person with IBD become dysbiotic? Is dysbiosis just a secondary phenomenon of IBD, or is it actually a cause of IBD? …. [A] Western diet, modern infant nutrition, antibiotic use patterns, and public health measures may favour the growth of relatively aggressive resident bacteria at the expense of beneficial commensals. (Sartor RB. Intestinal microflora in human and experimental inflammatory bowel disease. Curr Opin Gastroenterol 2001;17:324–30.)[8]

post-2282-Human-Microbiome-Project-Decod-YCSc

THE GUT AND AUTISM

The most profound claim is that autism itself may be caused, assisted or worsened by altered gut microflora. We currently have well over 11 million children with ASD. Ever since Dr Wakefield published his landmark study in the Lancet, the association of gut flora and autism is one that won’t go away and for good reason. Dr. Wakefield, a pariah in mainstream medicine and demon non grata in the sequestered halls of the United Kingdom’s Ministry of Health and the CDC, has a legitimate and valid argument. He and other researchers who have vindicated his findings (there are several teams throughout the world) have seen profound improvements in autistic kids when put on a gluten free diet (radio interview on the Alex Jones show).

Recently we have found that the GI tracts of autistic children are overgrown with a species of Clostridia. Clostridia produce phenols as a defense mechanism. Phenols in general are metabolic poisons. Phenol for example, is used as a powerful disinfectant in hospitals. For brain development, the human body needs sulfur (a sulfa group) to neutralize the toxicity of phenols, the activation of vitamin D3 and cholesterol into their active forms and many other processes. Although not yet proven researchers suggest that there is a connection between the shortage of needed sulfa groups and autism. An intriguing clue lies in the fact that autistic kids suffer from a genetic sulfur metabolism defect. Perhaps the leaky gut from gluten enteropathies, even subclinical, allows much of the phenol to enter the bloodstream and hence the brain through a damaged blood brain barrier. Other major suspects are gluten itself, excitotoxins, and exorphins the morphine-like compounds found in abundance in most grains and cheese. Of course vaccines, as I point out, play a definitive role in the genesis of autism and autoimmunity (as professor Clause Woodnit swallows his pipe from such blasphemy).

I think this is a good time to remind you that sulfur, a pulpit preacher’s brimstone, is crucial for some of the body’s most important functions such as the conversion of cholesterol and vitamin D3 into their bio-active forms-in the presence of toxic, cancer causing sunlight. I frequently bath in Epsom salts as per Dr Seneff’s suggestion which provides the sulfa groups desperately needed for human metabolism. Cruciferous vegetables and egg yolks are another good source but I found them too cumbersome to bathe in.

In Biological Treatments for Autism and PDD by William Shaw PhD, he mentions that children with severe mental-emotional disorders such as autism and schizophrenia have very high circulating serum levels of a phenylalanine breakdown chemical known as HPHPA.[9] It is generated from Clostridia species in the gut a known pathogen under certain circumstances and in excess under certain forms of dysbiosis. It can be eliminated using the powerful drug Flagyl or a good alternate vancomycin often leading to improvements in patient symptoms. Dr Shaw:

The significance of this compound is that it is a probable metabolite of m-tyrosine (3-hydroxyphenylalanine), a tyrosine analog which depletes brain catecholamines and causes symptoms of autism (stereotypical behavior, hyperactivity, and hyper-reactivity) in experimental animals.

On his website Dr Shaw relates:

My research with fungal metabolites, oxalate production, cholesterol deficiency, and specific mitochondria markers has been very rewarding. All of these areas of research led to my understanding of the extent to which these abnormalities can affect the brain and body. The medical community had previously thought that these types of abnormalities were of little to no significance for most of the population. We are finding out that in some predisposed people, these abnormalities lead to behaviors such as the ones associated with Autism, OCD, Depression, and Alzheimer’s. Furthermore, they contribute to complex immune reactions such as the ones found in Parkinson’s disease, Cystic Fibrosis and autoimmune diseases. The ground work is being laid for some very promising treatments to take place.[10]

When it comes to gut flora we have taken all of this for granted. Your DIB I’m sure never once inquired about your microbiome but it is time to wake up and smell the flora (yes Anaximander go over there and take a whiff).


[1] (http://www.zonediet.com/blog/2011/07/the-key-to-a-healthy-gut/) Original: Round JL, Lee SM, Li Jennifer, Tran G, Bana J, Chatila TA and Mazmanian SK. “The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota.” Science DOI:10.1126/scienc.1206095 (2011)

[2] (http://www.zonediet.com/blog/2011/07/the-key-to-a-healthy-gut/) Original: Moreno S, Scheyer T, Romano CS, and Vojnov AA. “Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition.” Free Radic Res 40: 223-231 (2006)

[7] IBID

[8] (http://gut.bmj.com/content/53/1/1.1.full) 12/20/2012. Original: Gut 2004;53:1-4 doi:10.1136/gut.53.1.1

[9] Nutr Neurosci. 2010 Jun;13(3):135-43.

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Category: Dysbiosis

About the Author ()

Dr. Christopher Rasmussen (aka Reality Renegade) is the author of his upcoming book, "InflaNATION: Industrial Diners & A Doc In The Box." By deliberately avoiding harmful industrial foods and the Commercial Sick Care System with its Pills and Procedures paradigm, Dr Rasmussen cured himself of a deadly disease-which became the reason for writing this book. In the book, he provides the facts you must know and the solutions to regain your health, maintain wellness, and outlive your parents' generation in an extraordinarily toxic world.

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